The 25-year-old was sent off by referee Jon Moss for raising his foot and clashing with City goalkeeper Ederson in Liverpool's 5-0 defeat on Saturday
The Reds have the option to claim excessive punishment which could see Mane's ban reduced by either one or two matches
Only a claim of wrongful dismissal would see Mane's ban completely withdrawn but that is unlikely so the Senegal international still faces at least one game out
Mane collided with Ederson after 37 minutes with Manchester City 1-0 ahead.
The Brazilian goalkeeper needed eight minutes of treatment before he was taken off on a stretcher and wearing an oxygen mask
However, he returned to the City bench in the second half
The hosts went on to win 5-0 and Liverpool boss Jurgen Klopp said after the game the club was unlikely to appeal
He said: "So it never works? It would be another waste of time, like the game today
Not sure (if they will appeal)."
"I think everyone knows he didn't see the goalie
"There was not one second he looks on the goalie
He just wanted to get the ball as soon as possible
Hopefully the goalie is not seriously injured.
"(Sadio) is very, very upset
We couldn't keep him - he was shocked about the situation
I am sure also about the decision."
Source : PA
Source: PA