The visitors took the lead with a first half penalty conversion by Shaun Maloney after Martin Skrtel had fouled Victor Moses.
Luis Suarez hit back right after half time, giving the Reds hope, which soon faded as Wigan took the lead again through Gary Caldwell after some poor defensing.
The Latics held on to claim the three points, lifting them out of the relegation zone. Five defeats in six for Liverpool.
Full report to follow.