Luis Suarez, Steven Gerrard, Joe Allen, Daniel Agger and Martin Skrtel are all set to be rested ahead of Sunday's Premier League clash with Chelsea.
With Suarez out the Liverpool boss is likely to be looking to Samed Yesil to provide the goals in Moscow.
The Reds are six points clear in Group A, so Rodgers can afford to try out his younger squad, and Adam Morgan and Michael Ngoo may also feature.