Matchworks developer Urban Splash told the Daily Post that LiverpoolFC.TV would take two units at the site, totalling 11,120 sq ft, on a six year lease.
The channel will employ 20 people and will launch in September. It intends to broadcast six hours of original programming content a day, five days a week.
The space at Matchworks will be used as a TV studio and will also be home to the production arm of the website, which - with over a million fans logging on each month - is one of the most visited football club websites in the world.
Stephen Michael, general manager of LiverpoolFC.TV, said: "After a long search for appropriate premises, we were delighted to settle on the Matchworks.
"The space is very contemporary, hugely flexible and has proven to be perfect for our new headquarters and television studios.
"We are very much looking forward to getting established in our new home."
LFC.TV joins Riverside Home Ownership, part of the Riverside Group, one of the UK's leading social housing and regeneration organisations; Maritime Housing Association, part of the Regenda Group; Four Soft UK, the world's largest transport & logistics software provider; labour resource provider for manufacturing and logistics operations, Driving Edge and Family Martial Arts and Character Development Centre in Matchworks II.
Lynn Haime, associate director of Urban Splash, said: "We're pleased to welcome LiverpoolFC.TV to Matchworks II and their creative use of the space reflects the versatility of the accommodation we have to offer here - and there are plenty of fans in the office who are very excited about our latest signing.
"We're now over 60% let in the scheme with interest in the last few units at Matchworks II and also in our new Matchbox which will be ready to occupy later this year."Š Š
Urban Splash has five units remaining at Matchworks II ranging from 2,585 sq ft to 9,282 sq ft. Rents are £3.50 per sq ft for studio/workshop space and £7.50 per sq ft for fully fitted office space.
Also on the same site is the Matchbox, the first new build by Urban Splash in Liverpool, which will provide 19,000 sq ft of Grade A office accommodation.