Craig Bellamy picked up an ankle injury before Sunday's game with Manchester United and will play no part in the match, allowing Robbie Fowler to return for his first game of the season.
Fabio Aurelio has a groin injury, while Sami Hyypia, Steven Gerrard and Xabi Alonso are expected to play no part in the game.
Instead, Benitez will rely on his fringe players and give them much-needed first team experience.
Team (from): Reina, Peltier, Agger, Carragher, Palleta, Smith, Riise, Garcia, Sissoko, Pennant, Guthrie, Crouch, Kuyt, Fowler, Zenden, Warnock, Finnan, Martin.
