A victory would all but guarantee progression in the Champions League, and Benitez knows all about the opposition.
"We need to win and in our mind we want to win the game," said the Liverpool boss. "It's important we don't lose the match.
"We know exactly what they will do and how they will play. Depor like to keep the ball and we know there will be a lot of passion at their ground.
"But I believe we are playing well enough to get what we want. In the first half against them at Anfield, it was the best we have played all season.
"We have won games since but people can get excited about us winning games but you only judge yourselves against good teams, and they are a very good team."