The Argentina captain believes beating Everton at Goodison on Sunday will be the best way for the Reds to bounce back from their Champions League exit.
"We know that in the league we have got to start winning - and winning soon - as we are not in the top four," said Mascherano.
"This is strange for the club and the supporters because in the last four years we have always been in there, fighting for the title or to get into the Champions League and we need to start winning games, so that we can do that again.
"We know it is going to be very difficult on Sunday but this is a really important game for us and for our supporters and we have got to start winning in the league again by beating Everton."