Steven Gerrard, Robbie Keane, Jamie Carragher, Dirk Kuyt and Xabi Alonso are all expected to get a break while Diego Cavalieri, Sami Hyypia, Yossi Benayoun and Jermaine Pennant are likely to feature.
"We have enough players in the squad waiting for their chance to impress, it will be important for them to grab this opportunity," said the Liverpool boss. "And when the team is playing well it is easier to change players and retain the system.
"I believe we can still continue to play well and to keep winning regardless of the players we use.
"We want to win every game but this is another competition and we have several players who are tired after some difficult weeks so we rest some and change a few."