Houllier said: "It doesn't look good. I think he has pulled his hamstring and I don't think he will be alright."
With Djimi Traore needed at centre-back due to the injury of Stephane Henchoz, it remains to be seen who Houllier will use at left-back.
Jamie Carragher would of course be the favourite, but he is the only right-back currently at the club.
